Research Scientist/ Research Investigator

Compensation

: $88,620.00 - $151,450.00 /year *

Employment Type

: Full-Time

Industry

: Scientific Research



Arvinas is a pharmaceutical company focused on developing new small molecules - known as PROTACs (PROteolysis TArgeting Chimeras) - aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting \"undruggable\" as well as \"druggable\" elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.

Senior Research Scientist/ Research Investigator, DEL Cheminformatics
Reports to: David Langley, Sr. Director Platform Chemistry
Arvinas is a pharmaceutical company focused on developing new small molecules - known as PROTACs (PROteolysis TArgeting Chimeras) - aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting \"undruggable\" as well as \"druggable\" elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit www.arvinas.com.
Position Summary
As one of the key hires for the company, this individual will work in close collaboration with leaders and scientists to ensure progression of PROTACs against oncology and neurology disorders. This highly motivated individual with expertise in cheminformatics and molecular modeling will be the point person for DNA Encoded Library cheminformatics. This position reports to the Sr. Director of Platform Chemistry and will be located at our headquarters in New Haven, CT.
Primary Responsibilities
* Support and drive the discovery and advancement of targeted protein degraders (PROTAC^ molecules) through DNA Encoded Library (DEL) design and data analysis.
* Designing DEL's for the identification of target and E3 ligase ligands.
+ Work closely with DEL and Medicinal Chemistry to design libraries
+ Develop and maintain strong knowledge of DEL chemistry for multi-cycle libraries
+ Build and maintain mono-, di-, and tri-functional reagent database
+ Monitor DNA codon performance stability
+ Assemble virtual DEL's and calculate chemical property and feature profile
+ Select reagents for library synthesis in collaboration with DEL & Medicinal Chemistry teams
+ Analyze raw Next Generation Sequencing (NGS) data for feature profiles
+ Monitor and maintain compound deck architecture
+ Work with team to order and register reagents and DNA codons
+ Maintain DEL codon, reagent and library database
* Actively participate in collaborative drug discovery projects acting as key contact for technical discussions with external collaborators.
* Engage in cutting edge scientific research, within Arvinas and with our collaborators
Qualifications
* Direct experience in DEL library design and NGS data processing preferred
* Deep background in cheminformatics
+ Knowledge of cheminformatic descriptors and formats, clustering methods, QSAR/QSPR
* Strong Python programming and Linux scripting skills (csh and/or bash)
* Knowledge in web-based programming and/or AI is a plus.
* Solid background in statistics, knowledge of R and/or MATLAB
* Knowledge of pipelining software (KNIME / Pipeline Pilot)
* Solid experience in data visualization
* Working knowledge of synthetic organic chemistry
* Experience in drug discovery and SAR analysis
* Additional experience in at least two of the following molecular modeling areas: QSAR/QSPR, virtual ligand screening, computationally-driven lead optimization, ligand-based drug design, homology modeling.
* A successful candidate will have an entrepreneurial attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas
* High degree of independence
* Excellent communication skills
* Maintenance of accurate records
Education
* PhD, or M.S/ B.S. scientist with 8+ years of pharma/ biotech/ academic experience in computational chemistry, cheminformatics, organic chemistry, physics, biochemistry, or a related field.
Please send CV and cover letter to: ...@arvinas.com
Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com
Arvinas is an Equal Opportunity employer
Arvinas, Inc.
5 Science Park
395 Winchester Ave
New Haven, CT 06511
USA
+1.203.###.####
...@arvinas.com
...@arvinas.com
...@arvinas.com
...@arvinas.com
...@arvinas.com

* Direct experience in DEL library design and NGS data processing preferred * Deep background in cheminformatics + Knowledge of cheminformatic descriptors and formats, clustering methods, QSAR/QSPR * Strong Python programming and Linux scripting skills (csh and/or bash) * Knowledge in web-based programming and/or AI is a plus. * Solid background in statistics, knowledge of R and/or MATLAB * Knowledge of pipelining software (KNIME / Pipeline Pilot) * Solid experience in data visualization * Working knowledge of synthetic organic chemistry * Experience in drug discovery and SAR analysis * Additional experience in at least two of the following molecular modeling areas: QSAR/QSPR, virtual ligand screening, computationally-driven lead optimization, ligand-based drug design, homology modeling. * A successful candidate will have an entrepreneurial attitude, be a problem solver and have a desire to work in a collaborative manner across all the functional areas * High degree of independence * Excellent communication skills * Maintenance of accurate records, * PhD, or M.S/ B.S. scientist with 8+ years of pharma/ biotech/ academic experience in computational chemistry, cheminformatics, organic chemistry, physics, biochemistry, or a related field.

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com
Reports to: David Langley, Sr. Director Platform Chemistry, Please send CV and cover letter to: ...@arvinas.com, 5 Science Park 395 Winchester Ave New Haven, CT 06511 USA +1.203.###.#### ...@arvinas.com ...@arvinas.com ...@arvinas.com ...@arvinas.com ...@arvinas.com


Associated topics: biomedical, dietetic, dietician, drug development, drug discovery, histologist, kinesiology, microbiology, nutritionist, therapeutic * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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