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Job Description

Duties:

Perform drug concentration bioanalysis of siRNA and major metabolites by LC-MS(/MS) in support of PK and TK studies for multiple drug candidates.

Develop LC-MS(/MS) methods to support siRNA and major metabolites bioanalysis in a variety of biological matrices. Perform method qualification in house and support method transfer to external CRO.

Perform metabolite profiling of siRNA compounds by LC-MS(/MS), analyze and interpret resulting data in support of understanding siRNA drug metabolism.

Support LC-MS instruments operation and daily maintenance.

The successful candidate is expected to have the following qualifications:

Hands on experience in performing laboratory procedures and conducting experiments.

Experience with LC-MS methodologies and instrumentation.

Previous experience with quantification of analytes in biological samples using LC-MS is strongly preferred.

Previous experience with oligonucleotide is strongly preferred.

Previous experience with HRAM mass spectrometry and LIMS is a plus.

Working knowledge of Microsoft Office (Excel, Word, PowerPoint).

Ability to multi-task and work in a fast paced working environment.

Excellent interpersonal skills and a team player.z

Qualifications

A Masters or Bachelors degree in biology, biochemistry, chemistry, or relevant field, with 1 year or 3 years of biopharmaceutical experience respectively.


Associated topics: aseptic, biopharmaceutical, dietician, disease, food, immuno oncology, immunohematology, pharmacometrics, therapy, virus

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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